Spreading Depolarizations (SD)
Curated resources on spreading depolarization
Browse webinars, interviews, and publications focused on SD, bringing together experimental research and clinical perspectives in one place for deeper exploration.
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Automated Detection of Spreading Depolarizations in Electrocorticography
Jed Hartings and Sreekar Puchala explore real-time, automated detection of SDs in electrocorticography, highlighting the potential of algorithmic monitoring to enhance clinical adoption, reduce reliance on manual review, and offer new insights into SD waveforms through systematic, cloud-based analysis.
WAVEFRONT: Noninvasive, Automated Detection of Cortical Spreading Depolarizations Using Scalp EEG
Dr. Alireza Chamanzar & John McNamee from Precision Neuroscopics discuss WAVEFRONT, which allows users to review detections, temporal and spatial signal patterns, propagation speed, as well as CSD frequency over time.
An Approach to Visualize and Detect Features of Brain Injury Progression
Dr. Baptiste Balança & Dr. Valentin Ghibaudo explore how to visualize and analyze the interplay between markers of cortical injury such as CSD and subcortical impairment such as heart rate and respiratory rate variability.
Identification of Spreading Depolarizations in Bedside ECoG with Moberg CNS
Jed Hartings covers methods for recording SDs, characteristics of SDs, and using Moberg software to help identify SDs.
Spreading Depolarizations: A Comprehensive Overview
Jed Hartings, PhD (University of Cincinnati), shares his work about SDs. This webinar session covers basic science of how SDs mediate infarct development, how to collect recordings in patients, and clinical importance of SD monitoring
Interviews & Podcasts
Conversations with clinicians and neuroscientists exploring SD research, key translational challenges, and what these insights may mean for the future of critical care practice, multimodal brain monitoring, and patient management.
Listen to expert discussions and firsthand perspectives on emerging discoveries, unresolved questions, and real-world experiences in SD research and brain monitoring.
Visit the full Interviews and Podcasts page to discover more perspectives and in-depth discussions.
Multimodal Monitoring with Jed Hartings and Brandon Foreman
Jed Hartings, PhD and Brandon Foreman, MD talk with us about multimodal brain monitoring and SD. They discuss the individual paths they took that led to the University of Cincinnati where they helped build one of the premier multimodal monitoring services in the U.S.
Publications
A curated set of peer-reviewed studies and academic work on SD, covering mechanisms, detection, clinical relevance, and ongoing advances in brain injury research. Publications are organized by the newsletter editions in which they were previously featured, making it easy to explore them in context.
Explore all publications to stay up to date with the latest findings in the field.
November 2025
Balança, B., Ghibaudo, V., […], Berhouma, M. (2025). Feasibility and safety of electrocorticography monitoring after acute brain injury to detect cortical spreading depolarisation, a prospective observational study in a neurological intensive care unit. Anaesth Crit Care Pain Med. https://doi.org/10.1016/j.accpm.2025.101669.
July 2025
Rosenthal, Z., Majeski, J., Somarowthu, A., […], Goldberg, E. (2025). Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans. Nat Commun. https://doi.org/10.1038/s41467-025-59900-1.
September 2024
Carlson, A.P., Jones, T. Zhu, Y. et al (2024). Oxygen-Based Autoregulation Indices Associated with Clinical Outcomes and Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care. https://doi.org/10.1007/s12028-024-02088-x.
Videos
Informative videos exploring this phenomenon.
Spreading Depolarizations
This educational documentary introduces the novice to SDs as well as the interesting history surrounding their discovery. Filmed at sites in the U.S. and Europe, the documentary describes the current understanding of these physiological biomarkers of brain injury as well as what the future might hold for their clinical utility.
Additional Websites
For deeper exploration of spreading depolarizations, additional materials and resources are available through these external website.
COSBID.org
COSBID.org
