Spreading Depolarizations - Neuromonitoring

Spreading Depolarizations (SD)

Curated resources on spreading depolarization

Browse webinars, interviews, and publications focused on SD, bringing together experimental research and clinical perspectives in one place for deeper exploration.

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Webinars

A curated selection of expert-led sessions from the Case Studies in Neurocritical Care AI webinar series, exploring spreading depolarization, its role in secondary brain injury, and emerging approaches to detection and multimodal brain monitoring in clinical and translational research settings.

Visit our Webinars page to browse the full library of sessions across a wide range of related topics and areas of interest.

Automated Detection of Spreading Depolarizations in Electrocorticography

Jed Hartings and Sreekar Puchala explore real-time, automated detection of spreading depolarizations in electrocorticography, highlighting the potential of algorithmic monitoring to enhance clinical adoption, reduce reliance on manual review, and offer new insights into SD waveforms through systematic, cloud-based analysis.

Webinar Series: WAVEFRONT: A noninvasive, Automated Detection technique for cortical spreading depolarizations using scalp EEG with speakers Dr. Alireza Chamanzar & John McNamee

WAVEFRONT: Noninvasive, Automated Detection of Cortical Spreading Depolarizations Using Scalp EEG

Dr. Alireza Chamanzar & John McNamee from Precision Neuroscopics discuss WAVEFRONT, which allows users to review detections, temporal and spatial signal patterns, propagation speed, as well as CSD frequency over time.

An Approach to Visualize and Detect Features of Brain Injury Progression

Dr. Baptiste Balança & Dr. Valentin Ghibaudo explore how to visualize and analyze the interplay between markers of cortical injury such as CSD and subcortical impairment such as heart rate and respiratory rate variability.

Interviews & Podcasts

Conversations with clinicians and neuroscientists exploring SD research, key translational challenges, and what these insights may mean for the future of critical care practice, multimodal brain monitoring, and patient management.

Visit the full Interviews and Podcasts page to discover more perspectives and in-depth discussions from across the field and related disciplines.

Interview

Multimodal Monitoring with Jed Hartings and Brandon Foreman

Jed Hartings, PhD and Brandon Foreman, MD talk with us about multimodal brain monitoring and SD. They discuss the individual paths they took that led to the University of Cincinnati where they helped build one of the premier multimodal monitoring services in the U.S.

Publications

A curated set of peer-reviewed studies and academic work on SD, covering mechanisms, detection, clinical relevance, and ongoing advances in brain injury research. Publications are organized by the newsletter editions in which they were previously featured, making it easy to explore them in context.

Explore all publications to stay up to date with the latest findings in neuromonitoring.

November 2025

Balança, B., Ghibaudo, V., […], Berhouma, M. (2025). Feasibility and safety of electrocorticography monitoring after acute brain injury to detect cortical spreading depolarisation, a prospective observational study in a neurological intensive care unit. Anaesth Crit Care Pain Med. https://doi.org/10.1016/j.accpm.2025.101669.

July 2025

Rosenthal, Z., Majeski, J., Somarowthu, A., […], Goldberg, E. (2025). Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans. Nat Commun. https://doi.org/10.1038/s41467-025-59900-1.

September 2024

Carlson, A.P., Jones, T. Zhu, Y. et al (2024). Oxygen-Based Autoregulation Indices Associated with Clinical Outcomes and Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care. https://doi.org/10.1007/s12028-024-02088-x.